Drug Reaction with Eosinophilia and Systemic Symptoms, or DRESS, is a rare drug reaction and can be lifethreatening in some cases. This is a report of a 55-years-old woman who presented to the Emergency Room of our hospital with a diffuse morbilliform eruption, approximately one month after starting to take Allopurinol for her gout. In addition to the dermatological manifestations, she developed other systemic manifestations (hepatic and cardiovascular) very rapidly and expired as a result of complications secondary to DRESS.