Serena X. Zhang*, Elizabeth A. Taylor, and Nicholas F. Logemann
Azathioprine is an immunosuppressive agent that poses an increased risk of developing squamous cell carcinomas to include the self-involuting squamous cell carcinoma variant, a keratoacanthoma. The development of multiple keratoacanthomas is considered rare and there are limited reports in the literature of multiple keratoacanthomas developing in patients after exposure to azathioprine. We present a case of multiple keratoacanthomas developing after 28 years of azathioprine use in a patient without any genetic predisposition.