Elizabeth T Dom-ogen* and Joanna I Alafag
Diabetes mellitus is a condition defined by persistently high levels of sugar (glucose) in the blood affecting the population of both developed and developing countries. This has two types but the most widespread type is Type II which may be correlated with the stress, sedentary lifestyle and unhealthy food consumption. This ailment is being treated with synthetic agents but causes many side effects. That is the reason why herbal tea are widely used up-to-date to aid against various diseases like diabetes mellitus for the reason that they contain helpful active chemical constituents. The present study aimed to investigate the physico-chemical and stabilization effect of Lemon Grass (Cymbopogon citratus Stapf) aqueous extract on glucose-induced Sprague Dawley rats compared to distilled water as the negative control and glibenclamide as the positive control using OECD no. 23 and oral glucose tolerance test (OGTT). CCAE were prepared based on how tea is consumed and administered orally to SD rats. The blood glucose level reading in the three treatments were done by puncturing the SD rats tail vein in -30, 0, 10, 30, 60, 120 and 240 minutes. A single dose of 2,000 mg/kg body weight CCAE during the 14-day observation period did not exert any abnormal physical sign or symptom and death. The blood glucose level of SD rats in CCAE treated group was within the normal range at 30, 60, 120 and 240 minutes while for distilled water treated group, it was observed at 60, 120 and 240 minutes. For glibenclamide treated group, the glucose blood level is within the normal range at all time. From this, it could be concluded that CCAE is safe for consumption and it stabilizes glucose-induced hyperglycemic SD rats in 30 minutes after ingestion. It is further recommended for other clinical studies to confirm the claim that could be helpful for the management of type II diabetes.