Subramaniam Suresh, Embong Zunaina, Ismail Shatriah and Ab-Rahman Azriani
Objectives: The aim of this study is to determine the sensitivity and specificity between leaking status using FFA and edema status using HRT III and OCT to detect macular edema, and also to determine the agreement of edema status seen between HRT III and OCT in diabetic macular edema (DME).
Methodology: Sixty seven patients with DME were selected for this study. They were subjected to HRT III and OCT to get edema values. Finally FFA examination was done to see the leaking area and served as the gold standard in this study. The results using HRT III and OCT were each compared with FFA, and the agreement of edema status between HRT III and OCT were analysed.
Results: Topographic edema map of HRT III has relatively better sensitivity and specificity (78.1% and 76.6% respectively) compare with edema index of HRT III (74.2% and 72.6% respectively) to detect DME. Topographic edema map of OCT has relatively better sensitivity and specificity (68.7% and 85.0% respectively) compare with macular thickness value of OCT (48.6% and 78.1% respectively) to detect DME. There is fair agreement (r = 0.252, p < 0.001) between edema index of HRT III and macular thickness value of OCT, while other modules of HRT III and OCT has moderately good agreement (r = 0.455 to 0.497, p < 0.001) in detecting edema status in DME patients.
Conclusion: Both topographic edema map of HRT III and OCT have relatively better sensitivity compare with other modules to detect DME. Good agreement exists between HRT III and OCT in detecting edema in DME patients.