天然物の化学と研究

Acute Toxicity (LD₅₀) Studies Using Swiss Albino Mice and Brine Shrimp Lethality (LC₅₀ and LC₉₀) Determination of the Ethanol Extract of Stem Bark of Echinaceae angustifolia DC.

Abdu Zakari and Dimas Kubmarawa

The ethanol extract of Echinaceae angustifolia DC was tested for acute toxicity (LD₅₀) using Swiss Albino Mice and was screened for Brine Shrimp lethality using Artemia salina larvae. The results showed that the plant was toxic to the mice at even a lower concentration (300 mg/Kg) and caused death at a concentration of 500 mg/Kg body weight of the live mice. The LD₅₀ was found to be 3,807.89 mg/Kg. The result of the Brine Shrimp lethality showed that the extract was toxic to the naupli with an LC₅₀ and LC₉₀ values of 125.89 μg/mL and 794.33 μg/mL respectively.